Gallbladder cholesterol cholelithiasis represents a failure of biliary cholesterol homeostasis in which the physicalcherm ' cal balance of cholesterol solubility in bile is disturbed the pathophysiologic defect in both mice and humans is unphysiologic cholesterol supersaturation of gallbladder bile .

胆囊胆固醇结石病表现为胆汁中胆固醇的内环境的失衡，即胆固醇在胆汁中溶解的生理-生化平衡被打乱。胆囊胆固醇结石的病理生理缺陷 表现为 ：胆囊中胆汁的 胆固醇 非 生理 性过饱和。