Relationship Between Matrix Metalloproteinase-9 Expression in Syncytiotrophoblast and Placenta Pathological Change of Intrauterine Growth Restriction

胎儿生长受限胎盘病理改变与 绒毛 滋养 细胞基质金属蛋白酶9的表达关系

Conclusion One of the possible mechanism involved in perinatal of ICP is apoptosis caused by overexpression of bax in syncytiotrophoblast leading placental dysfunction .

结论ICP患者 胎盘 合体 滋养 细胞bax基因过度表达，胎盘细胞凋亡率升高，影响胎盘功能，可能是ICP并发围生儿 缺氧 的 病理 生理 基础之一。

Leptin expressed on the placenta villous syncytiotrophoblast .

Leptin主要表达于胎盘 合体 滋养层 细胞 的 胞 浆中。

Results The expression of bFGF and Bax were located in the plasma of all types of cells including trophoblast epithelial mesenchymal and fibroblast but the expression of Bcl-2 was only observed in the chorionic syncytiotrophoblast ;

结果bFGF和Bax在滋养细胞、上皮细胞、间充质细胞和成纤维细胞胞浆内有表达，Bcl-2在绒毛膜 合体 滋养 细胞上有 表达；

This leads to oxidative stress and damage to the placenta specifically to the syncytiotrophoblast .

这会导致胎盘的氧化应急和损伤，特别是对于 合 胞 体 滋养层。

Result Immunolocalization of VEGF in all cases was observed mainly in syncytiotrophoblast .

结果VEGF主要 表达 于 胎盘 绒毛 滋养 细胞；

Computer image analysis ( 1 ) The expression of VEGF in placenta syncytiotrophoblast cells : There was no significant difference between mild PIH group and NP group P > 0.05 ;

胎盘 滋养细胞VEGF染色 光度：轻度妊高征组和正常晚期妊娠组比较无显著差异，尸>0.05；中度妊高征组和轻度妊高征组比较无显著差异，尸>0.05；

Objective : To study the changes of the biochemical indexes in syncytiotrophoblast cell plasma membranes ( STCPM ) of pregnancy induced hypertension syndrome ( PIHS ) and the cause of these changes .

目的：研究妊高征（PIHS）患者胎盘 合体 滋养细胞质膜（STCPM）中生化指标的变化及原因。

The results showed that the positive rate of neoplastic syncytiotrophoblast ( ST ) ; intermediate trophoblast ( IT ) and cytotrophoblast ( CT ) was 100 % respectively .

结果表明，肿瘤性 合体 滋养 细胞（ST）、中间型滋养细胞（IT）及细胞滋养细胞（CT）内细胞角蛋白的阳性表达率均为100%。

Results HB-EGF expression was localized in the cytoplasm of cytotrophoblast and syncytiotrophoblast but no expression was present in those with spontaneous abortion .

结果HBEGF主要存在于细胞质， 合体滋养层和 细胞 滋养层 均有 表达，部分流产滋养细胞不表达。

Future studies will determine whether carbon monoxide can prevent syncytiotrophoblast death in animal models and whether other approaches similar to carbon monoxide may provide feasible protection .

进一步的研究需要确定一氧化碳是否可以在动物模型中抑制 合 胞 体 滋养层的死亡，以及是否有和一氧化碳相似的途径存在保护作用。

HE staining : To prepare paraffin sections of placental tissue observed them under high power lens of light microscope after HE staining to evaluate the interstitial fibrosis and necrosis of villus and syncytiotrophoblast nodes . 2 .

HE染色法分析：制作胎盘组织石蜡切片，HE染色后于光镜下200 倍 视野观察绒毛间质纤维化、坏死及 合体 滋养 细胞结节。

CONCLUSION : HCV persistent infection suppressed the synthesis and secretion of MMP-2 and MMP-9 of human placental syncytiotrophoblast in vitro which is not specific .

结论：丙型肝炎病毒持续感染时体外培养人胎盘 合体 滋养层 细胞MMP-2和MMP-9合成分泌 能力 下降，为非特异性。

Villi syncytiotrophoblast layer and cytotrophoblast and loose in the middle of stromal part .

绒毛组织 由 合体 滋养层及细胞滋养层及中间的疏松间质三部分所构成。

Results : KiSS-1 was mostly found in syncytiotrophoblast .

结果KiSS-1主要位于 胎盘 绒毛 小叶 的 合体 滋养 细胞。

The Analysis of Fatty Acid Composition in Syncytiotrophoblast Plasma Membranes of Human Placenta

人体胎盘 合体 滋养 细胞质膜的脂肪酸组成分析

Western blot was applied to determinate the expression of IDO protein on cultured syncytiotrophoblast ;

westernblot检测体外培养的 合体 滋养层 细胞IDO蛋白质表达；

Results : Ability of invasion adhesion migration and function of hormone synthesis and secretion of infected syncytiotrophoblast decreased significantly in comparison with cells of control group ( P < 0.05 ) .

结果：感染 组细胞侵袭、黏附、移动以及激素合成分泌功能较对照组均有显著下降（P<0.05）。

The bulk of the human placenta consists of branching chorionic villi with an outer syncytiotrophoblast underlying cytotrophoblasts and a stromal core .

人胎盘绒毛膜绒毛的结构由内向外依次是绒毛基质，细胞滋养层细胞和其外层的 合体细胞滋养细胞。

In pathological placentas there are significantly lower expression of MMP-9 in syncytiotrophoblast ( 18.2 % ) than those without pathological change ( 75.0 % P < 0.01 ) .

有病理改变的 胎盘 绒毛 滋养 细胞MMP-9的表达（18.2%）明显低于无病理改变胎盘（75.0%），差异有非常显著性（P<0.01）。

Mainly in epithelial cells of the amnion chorionic trophoblast nucleus syncytiotrophoblast membrane and cytoplasm of placenta .

结果AQP8 蛋白在羊水 过少 组 和 正常羊水组产妇的胎盘、胎膜组织中 均有 表达，主要分布于羊膜上皮细胞、绒毛膜滋养细胞核 胎盘 合体滋养细胞的细胞膜和细胞质中。

When syncytiotrophoblast cells die they are released into the maternal circulation initiating a cascade of inflammation that can damage maternal organs .

当 合 胞 体 滋养层细胞死亡，他们就会释放到母体的血液循环中，从而引起炎症级联反应，进而损害母体的器官。

Objective To study the relationship between matrix metalloproteinase-9 in syncytiotrophoblast and placenta pathological change of fetal growth restriction .

目的了解胎儿生长受限（ fetal growth restriction， FGR ） 者胎盘病理改变与胎盘组织中基质金属蛋白酶9（MMP-9）表达水平变化的关系。

Conclusion : HCV persistent infection suppressed the biological behavior of human placental syncytiotrophoblast in vitro .

结论：HCV持续感染可抑制体外培养人胎盘 合体 滋养层 细胞包括 侵袭 力 和 激素 合成、 分泌功能 在内的多种生物学功能。

Study on the Relation between Syncytiotrophoblast Microparticles and Pathogenesis of Preeclampsia

胎盘 合体 滋养 细胞膜微粒与子痫前期发病机制的关系研究

The results show : in hydatidiform moles syncytiotrophoblast of floating villi LN is negative ;

结果显示：LN在葡萄胎中的游离绒毛 合体 滋养 细胞 （ LNR ） 呈 阳性 着色、LN呈阴性；