As an intermediate for COX-2 inhibiters 4 - ( methylthio ) benzeneacetic acid (ⅳ) was prepared via Friedel-Crafts and Willgerodt-Kindler reaction from thioanisole (ⅰ) .

以 茴香 硫 醚（Ⅰ）为 原料，经Friedel-Crafts酰基化、 Willgerodt-Kindler反应合成了COX-2抑制剂的中间体4-甲硫基苯乙酸（Ⅳ）。