Improvement of dissolution rate of tolbutamide by the spherical crystallization technique

用球形结晶技术改善 甲苯 磺 丁 脲的溶出速率

Result : The DDDs of oral antidiabetic agents rised gradually from 2001 to 2003.The front of DDDs were among Gliclazide Tolbutamide and Metformin .

结果：2001～2003年我院口服降糖药的DDDs呈现逐年上升，其中格列齐特、 甲苯 磺 丁 脲、二甲双胍 位居前列；

In this paper the Caco-2 cell model was established and validated to study the absorption properties and mechanism of 8 oral anti-diabetics including gliclazide glipizide gliquidone metformin glibenclamide rosiglitazone tolbutamide and nateglinide .

本文建立并验证 Caco-2细胞模型，对八种口服降糖药物的体外吸收特性及吸收机制进行了研究。

X-ray diffraction studies on tolbutamide solid dispersion

甲苯 磺 丁 脲固体分散 物的X线衍射研究

Methodical study in improving dissolution of tolbutamide tablet

提高 甲苯 磺 丁 脲片溶出度方法的研究

P4502C9 substrates mainly include tolbutamide phenytoin S-warfarin fluoxetine and losartan .

P4502C9的底物包括 甲苯 磺 丁 脲、苯妥英、S法华令、氟西汀、洛沙坦等。

AIM To establish the methods for assaying the activities of tolbutamide hydroxylase ( CYP2C8 / 9 ) and chlorzoxazone 6-hydroxylase ( CYP2E1 ) from adult human livers microsomes .

目的建立 甲苯 磺 丁 脲羟化酶（CYP2C8/9）和氯羟苯口恶唑6羟化酶（CYP2E1）比活性的测定方法，为深入研究CYP450在药物代谢中的作用奠定基础。

An increased risk of cardiovascular death was associated to treatment with glimeperide glibenclamide glipizide and tolbutamide when compared with metformin ( Figure ) .

与二甲双胍相比当使用格列美脲、格列苯脲、格列吡嗪及 甲苯 磺 丁 脲降糖治疗时心源性死亡的风险增加。