Methods 3-one-12-hydroxy-13 was synthesized in a three-step route including protecting primary alcohol of andrographolide by trityl ether oxidating secondary alcohol and removing protecting group etc.

方法通过 三 苯甲醚保护伯醇、氧化仲 醇、脱去保护基的方法，合成3酮基12羟基 13烯穿心莲内酯。