Umbilical cord blood transplantation for patients with β - thalassemia major

脐血移植治疗重型β 地中海 贫血的临床研究

Twelve ( 8 males and 4 females ) patients with β - thalassemia major received the hematological stem cell transplantation ( HSCT ) .

12例接受造血干细胞移植治疗的重型β 地中海 贫血 患儿，年龄从25岁～115岁，男8例，女4例。

Conclusions It suggests that the PCR-RDB assay is effective in preventing the birth of β - thalassemia major and has clinical significance in improving the population quality .

结论PCR-RDB技术可有效减少β 地中海 贫血 重症 患儿的出生，具有 重要的优生学意义。

The purpose of this study was to designed to analyze and explore the diagnosis and treatment on a patient with β - thalassemia major accompanied with intestinal acute graft-versus-host disease ( aGVHD ) grade ⅳ after allo-peripheral blood stem cell transplantation ( allo-PBSCT ) .

对1例异基因外周血干细胞移植（alloPBSCT）治疗 重型β 地中海 贫血（TM）患儿合并Ⅳ度肠道aGVHD的诊断和治疗进行分析和探讨。

Prenatal diagnosis was carried out by the mentioned techniques above for fetuses who were in the risk of thalassemia major . 5 .

将上述方法运用于 重型 地中海 贫血 高风险胎儿的产前诊断中。

In 30 cases of thalassemia minor there were 28 cases of gene mutation heterozygotes 2 cases of which were dual gene mutations and 5 cases of thalassemia major were all dual gene mutations .

30例轻型β地贫中，28例为基因突变杂合子，2例是双重基因突变子；5例 重型 β 地贫中，均为基因双重突变子。

Conclusion β thalassemia heterozygotes conjuncted with α globin gene triplication was the major cause of the β thalassemia intermedia in this Korean family .

结论β 地中海 贫血 基因杂合子复合α珠蛋白基因组织增多是导致该家系中间型β地中海贫血的一个 重要分子病因。

Change of Serum Ferritin Level in Hyper Transfusion Thalassemia Major Children Treated by Different Dosage of Iron Chelator

不同剂量铁螯合剂治疗高量输血 重型 β 珠 蛋白 生成 障碍 贫血患儿血清铁蛋白的变化

A pair of twin girls suffered from thalassemia major .

一对孪生姐妹 婴儿患上了 重型 地中海 贫血。

Genetic Study on 27 Children with β - thalassemia Major and Their Parents in Sichuan Area

四川地区重型β- 地中海 贫血 患儿及双亲基因 突变的研究

Conclusion The results showed that Allo PBSCT was successful in treating β thalassemia major .

结论异基因外周血造血干细胞移植治疗 重型β 地贫 患儿已获得成功。

Treatment of thalassemia major with unrelated donor bone marrow transplantation

非血缘相关骨髓移植治疗 重型 地中海 贫血的临床研究

Transplantation with Combination of Umbilical Cord Blood and Neonatal Peripheral Blood in the Treatment of A Patient with β - thalassemia Major

脐带血、新生儿外周血混合移植治疗1例重型β- 地中海 贫血

Prophylaxis of Transplantation-related Complications after Allogeneic Stem Cell Transplantation in β - thalassemia Major

儿童重型β- 地中海 贫血异基因造血干细胞移植后并发症的防治

Multiple Regression Analysis of Liver Pathology and Other Factors in Children with β Thalassemia Major

重型β 珠 蛋白 生成 障碍 性 贫血肝脏病理与相关因素的多重回归分析

Most of dual gene mutations were thalassemia major but also observed in a few of thalassemia minor cases .

β地贫基因突变以点突变为主，双重基因突变子多为 重型 β 地贫，亦见于少数轻型β地贫。

Objective To reduce the birthrate of β - thalassemia major and improve the quality of population .

目的为了降低β 地中海 贫血 重症 患儿的出生率，达到优生的目的。

Meta-analysis of the efficacy and safety of combined therapy with deferiprone and deferoxamine in thalassemia major patients

去铁酮和去铁胺治疗 珠 蛋白 生成 障碍 性 贫血临床疗效及安全性的Meta分析

Conclusion This is the first report on successful transplantation of bone marrow stem cell for thalassemia major in China suggesting a new way to treat the disease and to expand the use of BMT .

结论骨髓造血干细胞移植可 根治 重型 地中海 贫血，为该病的治疗提供了新思路与途径。

Objective To reduce the birth rate of β - thalassemia major and improve the quality of population .

目的减少β- 地中海 贫血 重症 患儿的出生。

α - Thalassemia major is a hereditary disease with a syndrome of hemolytic anemia often caused bv the complete or partial deletion of a-globin genes .

α- 地中海 贫血是由于α-珠蛋白基因全部和部分缺失所致的一种遗传性溶血性贫血综合征。

Prenatal diagnosis of a case at-risk for compound heterozygotes of SEA HPFH deletion and β - thalassemia in a Chinese family . Combined transplantation of bone marrow and umbilical cord blood of same sibling in eight children with beta-thalassemia major

缺失型β- 地中海 贫血一个家系的产前诊断动员后的同胞骨髓联合脐血混合移植治疗儿童重型β-地中海 贫血8例

Objective To investigate the change of serum ferritin ( SF ) level in hyper transfusion thalassemia major ( TM ) children treated with different dosage of iron chelator .

目的探讨采用不同剂量铁螯合剂治疗高量输血 重型 β 珠 蛋白 生成 障碍 贫血（地贫）患儿1年后的血清铁蛋白（SF）的变化。

MR imaging of femoral marrow in treated β - thalassemia major

经治 重型β 地中海 贫血的股骨骨髓MR成像分析

Applying the methods mentioned to diagnose the fetuses who are in the risk of thalassemia major in prenatal diagnosis can prevent the births of these babies . 3 .

上述技术可应用于对 重型地贫 高风险胎儿的产前诊断，有效预防 重型 地中海 贫血 患儿出生。