The topology prediction of transmembrane protein is a hot in Bioinformatics .

跨 膜 蛋白拓扑结构预测是生物信息学的研究热点之一。

The study of transmembrane protein topology is very significant to discover transmembrane mechanism and function .

跨 膜 蛋白拓扑结构的研究对于揭示跨膜蛋白的作用原理与跨膜机制有着非常重要的意义。

And the result showed that MrpF was a three-time transmembrane protein . Based on computer prediction the fusion protein PhoA-MrpF was designed .

得出MrpF一种三次 跨 膜 的 膜 蛋白依据计算机预测的结构，设计了PhoA-MrpF融合蛋白。

The experimental results presented show that transmembrane protein structure prediction based on SVM could provide valid enhancement to transmembrane protein 3D structure prediction and function analysis .

本文详细的实验结果表明，基于SVM的 跨 膜 蛋白结构预测能够为跨膜蛋白3D结构预测和功能分析提供有价值的支持。

The probable general secretory pathway transmembrane protein ( GSP ) gene cluster is the center of the type II secretory system .

Ⅱ型分泌系统主要以分泌途径 转 膜 蛋白（GSP）基因簇为中心。

Bioinformatics analysis of the NAG 7 gene shows that it is a transmembrane protein containing a protein kinase C ( PKC ) phosphorylation site and a myristyl site .

它含有一个 蛋白激酶C磷酸化位点和 肉豆蔻基位点。

The M2 protein of AIV is a transmembrane protein . It has highly conserved antigenic epitopes and is a potential candidate antigen for avain influenza vaccine with cross-protection .

M2蛋白是禽流感病毒的 跨 膜 蛋白，含有高度保守的抗原表位，是理想的交叉保护性疫苗的候选抗原。

The Notch receptor is an evolutionarily conserved single-span transmembrane protein family and plays key roles in a wide variety of cell fate decisions during development of both invertebrate and vertebrate species .

Notch是一个进化上十分保守的跨 膜受体 蛋白家族，对无脊椎动物和脊椎动物发育过程中的细胞命运决定起重要作用。

Toll like receptor is a kind of type I transmembrane protein which is high conservative evolutionally . Toll like receptor is one of the most important components of innate immunity by recognizing different pathogen associated molecular pattern .

Toll样受体是一类在进化中高度保守的Ⅰ型 跨 膜 蛋白，识别病原体相关分子模式，为先天性免疫的重要成分，同时在机体特异性免疫过程中也起着关键性作用。

The predictions of signal peptide sequence and transmembrane helices in proteins indicated that the GST of P. yezoensis is a transmembrane protein with a signal peptide .

疏水性分析表明，GST基因氨基酸疏水性很强，有3个明显疏水区域。信号肽与跨膜结构预测显示条斑紫菜GST是一个具有信号肽的 跨 膜 蛋白。

The invariant chain ( Ii ) is a non-polymorphic type II transmembrane protein and plays a central role in regulating the expression and function of class II major histocompatibility complex ( MHC ) molecules .

Ii链是一种非多态性的Ⅱ型 跨 膜 蛋白，在调节MHCⅡ类分子的表达和功能方面发挥重要作用。

The lysosome-associated membrane protein ( LAMP-1 ) is a type 1 transmembrane protein which is localized predominantly in the outer membrane of lysosomes .

溶酶体相关膜蛋白（ lysosomeassociatedmembrane protein，LAMP）属I型 穿 膜 蛋白，主要定位于溶酶体外膜。

G P4 which encodes a transmembrane protein with 96 amino acid open reading frame .

T.g-P4编码96个氨基酸的 跨 膜 蛋白。

TACE is a multi-domain type I transmembrane protein in which opening reading frame encodes 824 amino acids .

TACE是多结构域的I型 跨 膜 蛋白，开放阅读框编码824个氨基酸。

Porin is a transmembrane protein found in the outer membrane of mitochondria as well as in the outer membrane of gram positive bacteria .

孔蛋白是一种 跨 膜 蛋白，主要存在于细菌质膜的外膜、线粒体和叶绿体的外膜上。

The ORF of this gene is 1083 bps long which encodes a 360-amino-acid transmembrane protein . It contains three transmembrane domains and one Popeye domain .

该基因的开放阅读框长1083bp，编码1个含有360个氨基酸的 跨 膜 蛋白，其结构域包括3个跨膜结构域和1个Popeye结构域。

Due to the limitation of current technical level and conditions experimental method to determinate the topology structure of transmembrane protein cannot keep up with the rapid increase of transmembrane sequences information .

限于当前的技术水平与条件限制，实验方法测定 跨 膜 蛋白的拓扑结构明显不能与快速增长的跨膜蛋白序列信息相适应。

Background : Receptor activator of NF - kappa B ligand ( RANKL ) is an important biological active substance which belongs to type ⅱ transmembrane protein found in tumor necrosis factor receptor ligand superfamily in recent years .

背景：核因子κB受体活化因子配基（receptoractivatorofNF-kappaBligand，RANKL）是人们近年来在肿瘤坏死因子受体配体超家族中发现的重要生物活性物质，属Ⅱ型 跨 膜 结合 蛋白。

Inflammation signal mediated by lipopolysaccharide ( LPS ) is transduced into cells by a transmembrane protein of Toll-like receptor 4 ( TLR4 ) resulting in a series of cytological effect .

细菌脂多糖（LPS）介导的炎症信号主要通过一种 跨 膜 蛋白toll样受体4（toll-likereceptor4，TLR4）传入胞内，引起一系列相应的细胞效应。

Muscle-specific kinase ( MuSK ) is a transmembrane protein which is related with acetylcholine receptor in the development of skeletal muscle MuSK is a primary ingredient to establish the main synaptic skeleton of the postsynaptic membrane formation .

肌肉特异性激酶（ muscle-specifickinase，MuSK）是一种与乙酰胆碱受体相关的 跨 膜 蛋白，在骨骼肌的发展中，MuSK是建立突触后膜时组建主要突触骨架的首要成分。

Transmembrane protein c-Met is the unique receptor of HGF coded by proto-oncogene c-met .

其单一受体c-Met是一 跨 膜 蛋白，由原癌基因c-met编码5w_425。

Bacteriorhodopsin is a transmembrane protein that can act as an energy switch on the cell membrane of halophilic bacteria it has a special proton pump function which can convert light energy into chemical energy for the vital activities used .

细菌视紫红质是嗜盐杆菌细胞膜上的一个能充当能量转换开关的 跨 膜 蛋白，它可以通过特殊的质子泵功能，将光能转换成化学能供自身各项生命活动所用。

Analysis indicated that the protein had no transmembrane helix zone it was not a transmembrane protein .

对该蛋白进行跨膜分析，结果表明该蛋白无跨膜螺旋区，不是 膜 蛋白。

Prolactin receptor ( PRLR ) is a single transmembrane protein through which prolactin plays a wide variety of physiological roles in vertebrates .

催乳素受体（Prolactinreceptor，PRLR）是单次 跨 膜的受体 蛋白，催乳素通过它在脊椎动物中起着广泛的生理作用。

Type I insulin-like growth factor receptor ( IGF-IR ) is a transmembrane protein . And it is also one of the main members of the family of receptor protein tyrosine kinases ( PTKs ) .

胰岛素样生长因子I受体（insulin-likegrowthfactorIreceptor，IGF-IR）为 跨 膜 蛋白，是酪氨酸蛋白激酶类受体家族的主要成员之一。

RTK has a perfect ORF that code proteins with signal-peptide and transmembrane region . It is predicted that the product of RTK may be a transmembrane protein with phosphorylation site .

RTK有一个完整的开放阅读框，其编码的蛋白质具有信号肽和跨膜结构域，可能是一个具有磷酸化功能的 跨 膜 蛋白。

However these methods mostly are limited to the use of one or several distinguishing features of transmembrane protein and they do not make an all-round and comprehensive use of various potential useful information . The prediction ability still needs to be improved .

但是这些预测方法大都局限于对 跨 膜 蛋白某一个或某几个显著特征的利用，不能全面的、综合的利用各种潜在的有用信息，其预测能力还有进一步提升的空间。

RVG is a transmembrane protein to form trimer located on the surface of the virus as spikes and the major surface antigen of the virus .

RVG是一种 跨 膜 蛋白，以三聚体的形式定位于病毒的表面，构成表面的纤突，是病毒的主要表面抗原。

A proliferation-inducing ligand ( APRIL ) a member of TNF superfamily is a typr II transmembrane protein with full length of 250 amino acids .

增殖诱导配体（aproliferation-inducingligand，APRIL），属于TNF超家族。Ⅱ 型 跨 膜 蛋白，全长250个氨基酸。