Objective To establish TK gene mutation assay using human lymphoblastoid cell line TK6 and to study the genotoxic mechanism of Vinblastine ( VBL ) .

目的建立用人类淋巴母细胞TK6检测纺锤体毒物& 长春 花 碱的TK基因突变试验方法，同时探讨 长春 花 碱的遗传毒性分子机理。

Contrast observation of clinical nursing of two kinds drugs of vinblastine sulfate

两种 长春 花 生物碱 类药物临床护理对照观察

Conclusions Interferon α 2b and vinblastine combination therapy showed high responses in patients with clear cell carcinoma whereas the response has been poor in other histologic types of metastatic renal cell carcinoma .

结论转移性肾癌干扰素与 长春 花 碱联合 生物化疗疗效与组织学类型有关，透明细胞癌缓解率高。

Studies have shown that vinblastine cannot be produced by cell culture in vitro synthesis in plants ; therefore exploring methods of alkaloid rise in Catharanthus roseus has important significance .

有研究证明， 长春 碱不能利用细胞培养的方法在植物体外合成，所以，探索使用其他方法使其生物碱量上升对长春花药用功效有重要意义。

Objective To investigate the optimal condition for complete removal of the template molecules from vinblastine ( VLB ) - imprinted polymer .

目的研究从 长春 碱（VLB）分子印迹聚合物中抽提模板分子的合适条件。

RESULTS ① P-gp detection shew that 54.5 % cases express a high resistance to doxorubicin mitomycin vinblastine .

结果①P-gp检测显示，54.5%的病例对阿霉素、丝裂霉素、 长春新碱等 抗生素 类 和 生物碱 类 抗癌 药高耐药。

Suitable stress is advantageous to the formation and the accumulation of vinblastine in the Catharanthus roseus .

适当的水肥胁迫有利于 长春 碱在长春花体内的形成和积累。

Vinblastine is a kind of alkaloid extracted from Catharanthus roseus which has anticancer bioactivity .

长春 碱是从夹竹桃科植物长春花（Catharanthusroseus）中分离得到的一种具有抗癌活性的生物碱。

Objective To compare the diverse effects of three kinds of antitumor drugs Camptothecin ( CAM ) Amsacrine ( AMSA ) Vinblastine ( VIN ) w_1275 on the cell cycle of lymphocytic cell line ( Molt 4 ) or human promyelocytic cell line ( HL 60 ) .

目的比较3种不同的抗肿瘤药物（喜树碱、胺苯吖啶、 长春 花 碱）对培养的淋巴细胞性（ Molt4）或髓样白血病细胞（HL60）的细胞周期的影响。

Effects of vinblastine nanoparticles on growth and apoptosis of glioma cell line C6

长春 碱纳米粒对C6神经胶质瘤细胞生长和凋亡的影响

Bovine embryos developing to the 5 ~ 10 cell stage were separated into individual blastomere with 0 5 % protease . After treatment with 100 ng / ml vinblastine sulfate for 10 h they were prepared for chromosome samples .

牛体外受精后5-～10-细胞期的胚胎用0.5%链霉蛋白酶处理分离单一卵裂球，然后用100ng/ml 长春 花 碱 处理 10h，制作染色体标本。

Vinblastine content only with below-branch height had significant negative correlation .

长春 碱含量仅与枝下高显著负相关。

Effect of Low Dose Vinblastine on Migration and Tubular Morphogenesis of ECV-304 Cells

低浓度 长春 花 碱对ECV-304细胞迁移及管样结构生成的影响

In this paper we established RP-HPLC determination method and sample preparation method and studied on the technology of vinblastine high effective extraction and purification and finished the middle experiment from fresh catharanthus roseus . And finally we established the new vinblastine produce process .

本文建立了 长春 碱的RP-HPLC分析方法和样品制备方法，研究了从鲜长春花中高效提取、纯化 长春 碱的方法，确定了全新的生产工艺，并进行了中试放大实验。

Cytotoxicity and acute toxicity study on vinblastine ( VLB ) nanoparticles granular cell ameloblastoma

长春 碱纳米粒的细胞毒性和急性毒性研究颗粒细胞性成釉细胞瘤

Antitumor drug vinorelbine tartrate was synthesised from vinblastine sulfate in 15.3 % overall yield .

从硫酸 长春 碱合成抗癌 药酒 石酸长春瑞宾，总收率15.3%。

Study on Treatment of ITP with Vinblastine Infusion into Spleen Artery Plus Embolectomy

脾动脉灌注 长春新碱加栓塞治疗ITP

Twenty hours after insemination the embryos were placed on a medium containing 100 ng / ml vinblastine sulfate and cultured for 8 and 10 hours .

废弃 牛 卵巢内卵子经体外成熟培养，体外受精20h后，在培养基中添加100ng/ml 长春 花 碱处理8h或10h。

Results Vinblastine inhibited basal glucose uptake by 24 % to 36 % .

结果 长春 花 碱抑制 C6细胞葡萄糖摄取24%～36%。

Effect of vinblastine and cytochalasin D on viscoelastic properties of hepatocellular carcinoma cells

长春 花 碱和细胞松驰素D对肝癌细胞粘弹性的影响

Clinical results and quality of life analysis for the MVAC combination ( methotrexate vinblastine doxorubicin and cisplatin ) in carcinoma of the uterine cervix : A Gynecologic Oncology Group study

宫颈癌患者氨甲喋呤、 长春新碱、阿霉素和顺铂（MYAC）联合化疗的临床效果及生活质量分析：一项妇科肿瘤协作组研究

Studies on Drug Release Characteristics and Anti-angiogenic Activity of Vinblastine Sulfate Thermosensitive Hydrogels

硫酸 长春 碱温敏性凝胶的释药特性和抗血管生成活性研究

Study on High Effective Extraction and Purification Process of Vinblastine from Catharanthus Roseus

长春 碱高效提取纯化的工艺研究

The adjuvant combined chemotherapy was followed with PVB ( cisplatin vinblastine and bleomycin ) or BEP ( bleomycin etoposide and cisplatin ) .

术后用PVB（顺铂、 长春新碱、博莱霉素）或BEP方案（博莱霉素、足叶乙甙、顺铂）化疗。