Tacrine is a selective acetylcholinesterase ( AChE ) inhibitor which has serious liver toxicity .

静脉 用 胺碘酮 致严重肝功能损害一 例 他 克林是一个选择性 较好但毒副作用明显的乙酰胆碱酯酶抑制剂。

Results Amnesia in mice can be prevented markedly after huperzine-A 0.4mg / kg Tacrine 40mg / kg or Galanthamine 4.0mg/kg is administered .

结果ig石杉碱甲0.4mg／kg或 他 克林40mg／kg或加兰他敏4.0mg／kg均能使小鼠的记忆障碍得到显著的改善。

Bioactive conformations were generated by docking a series of Tacrine Dimers Analogs with AChE crystal structure.3D quantitative structure activity relationship ( 3D-QSAR ) models were developed for AChE inhibitors using modeling analysis .

化合物的活性构象是通过一系列 他 克林二联体化合物与AChE晶体结构进行对接而获得的，以此进行建模分析，建立结构与活性之间的三维定量构效关系。

Tacrine in treatment of Alzheimer disease : a multicenter double-blind study in China

他 克林治疗阿尔采末病：在中国的多中心双盲研究

Despite this limitation tacrine has been widely used as scaffold for the development of new multifunctional agents with additional biological properties other than AChE inhibition .

尽管如此， 他 克林 仍被作为骨架广泛的应用于开发除了AChE抑制作用以外还具有其它生物特性的多功能药物。

Theoretical studies on the mechanism of inhibiting ache by tacrine and its analogues

他 克林及其类似物抑制乙酰胆碱酯酶机理的理论研究

Inhibition of tacrine on delayed rectifier and transient outward potassium currents in cultured rat hippocampal neurons

他 克林对培养大鼠海马神经元延迟整流钾电流和瞬间外向钾电流的影响

Aim To synthesize acylated prodrug of tacrine hydrochloride ( THA ) to improve the infiltration ability across the blood brain barrier ( BBB ) .

目的制备盐酸 他 克林（THA）的酰化前体药物以提高其透过血脑屏障（BBB）的能力。

OBJECTIVE : To synthesize Tacrine a new drug for the treatment of Alzheimer ′ s disease .

目的：合成 抗早 老性痴呆药 他克林。

The safety of tacrine has not yet been proven and there is concern that it causes damage to the liver .

他 克林的安全性尚未得到证实，有人担心它会对肝脏造成损害。

Comparision of pharmacokinetics of tacrine between young rats and aged rats

盐酸 他 可林在不同 月龄大鼠体内的药物动力学比较

Objective : To investigate the mechanism of liver injury of Tacrine and cell toxicity of several ginsenosides .

目的：探讨 他 克林的肝损伤机理及人参皂苷的 活性筛选。