Correlations of Topo ⅱα GST - π and P-gp expression with chemotherapeutic response and prognosis of epithelial ovarian carcinoma

卵巢癌中 Topo Ⅱα、 GST-π、Pgp表达与化疗反应性及预后的关系

We assayed the expression of P-gp GST - π and Topo ⅱ of 94 cases of human osteosarcoma by ABC immunohistochemistry for clinical formulation individual chemotherapy scheme and lengthening of the disease-free survival rate .

为此，我们采用ABC免疫组化法，检测了94例入骨肉瘤中P-pg、 GST-π、 TopoⅡ的表达，为临床制定个体化化疗方案，延长病人的无瘤存活期和生存率提供信息。

Construct for the first time a bilevel programming charactered by topo - logical structure fOr job-shop scheduling problems and the new model integrates the main three factors occured in the problem : scheduling lot and start-time .

6首次建立车间作业调度问题的具有 拓扑结构：的双层规划模型。新模型将此类问题的三个主要因素：调度、批量与加工时间的优化归结在一个模型内。

Methods : 90 patients with gastric carcinoma which had not been treated by chemotherapy radiotherapy or immunotherapy before surgery were studied for expression of P-gp TOPO ⅱ and GST - π using immunohistochemistry .

方法：应用免疫组化检测90例术前未使用过化疗、放疗及免疫治疗的胃癌组织中的Pgp、 TOPOⅡ和GST π的表达。

Purpose To investigate the role of expression of MDR1 / P-glycoprotein ( P-gp ) topoisomerase ⅱα( Topo ⅱα) and glutathione-S-transferase - π( GST - π) in chemotherapeutic resistance of breast cancer and their interrelationships .

目的了解多药耐药相关类蛋白P糖蛋白（Pgp）、谷胱甘肽S转移酶 π（GSTπ）、DNA拓扑异构酶Ⅱα（ TopoⅡα）在乳腺癌化疗耐药机制中的作用及相互间关系。

Using high-resolution echo-sounder side scan sonar and subbottom profiler to survey the seafloor We have obtained a lot of data about water depth topo - graphy morphology and the shallow stratigraphic texture of the survey area .

利用高分辨率的回声测深仪、 旁侧扫描声纳和浅地层剖面仪对海底进行探测，可获得调查区水深、底 形及底床下浅层沉积物结构等信息。

A Study on the Expression of P-gp 、 GST - π and Topo - ⅱ Proteins in Primary Epithelial Ovarian Cancer and Their Relationship with ATP-tumor Chemosensitivity Assay

P-gp、GST-π、 Topo-Ⅱ蛋白在上皮性卵巢癌组织表达及与ATP-肿瘤体外药敏关系的研究

Fluorescence spectrophotometric determination of trace uranium after extraction with TOPO

TOPO萃取-荧光分光光度法测定微量铀

The kinetics of the extraction of U ( IV ) chloride in the TOPO-HCl system has been studied using the single drop technique .

本文采用 上升 液滴法，研究了 三 辛基 氧化 膦（ TOPO） - 环己烷溶液从盐酸体系中萃取U（IV）的动力学。

Methods By using immunohistochemical S-P method the expressions of P-gp Topo ⅱα and GST - π were determined in 91 cases of untreated primary breast cancer and 18 cases of relapsed or metastatic breast cancer after chemotherapy .

方法用免疫组化SP法对91例未经抗肿瘤治疗的原发性乳腺癌和18例术后经化疗复治乳腺癌组织检测Pgp、GST π、 TopoⅡα蛋白表达。

Methods The expressions of P ? - gp GST ? - π and Topo ⅱ were detected in 60 cases of untreated primary breast cancer by using immunohistochemical S ?

方法用免疫组化S蛳P法对60例未经抗肿瘤治疗的原发乳腺癌检测P 蛳gp、GST蛳π及 TopoⅡ 蛋白 表达。

P-gp GST - π and Topo ⅱ showed low expressions in benign tumor . There were higher expressions in intraductal carcinoma in situ with early invasion and invasive ductal carcinoma of the breast than in intraductal carcinoma in situ of the breast .

P-gp、 GST-π和 TopoⅡ在良性病变中弱表达，在伴有早期浸润的乳腺导管内癌和乳腺浸润性导管癌中的表达同样明显高于乳腺导管内癌；

Aim : To determine the expressions of P-glycoprotein ( P-gp ) glutathione S-transferase Pi ( GST - π) and topoisomerase ⅱ( Topo ⅱ) in patients with breast cancer and evaluate their predictive value in neoadjuvant chemotherapy .

目的：评价乳癌组织多药耐药类蛋白P-糖蛋白（P-gp）、谷胱甘肽转移酶（ GST-π）、拓扑异构酶Ⅱ（ TopoⅡ）表达对新辅助化疗近期疗效的预测价值。

Evaluating the effect of intravesical chemotherapy by expressions of P-gp GST - π and TOPO - ⅱ in bladder cancer tissues

膀胱癌组织P-gp，GST-π和 TOPO-Ⅱ表达评估灌注化疗

RESULTS : The positive expression rates of Topo - ⅱα Ki-67 PCNA in low grade group were 28.5 % 21.4 % and 28.5 % respectively ;

结果：星形细胞瘤 Topo-Ⅱα、Ki-67和PC-NA的表达阳性率在低度恶性组中为28.5%、21.4%和28.5%；

Conclusion : The detection of P-gp GST - π and Topo ⅱ by immunohistochemistry is of important clinical significance to select chemotherapy and to judge prognosis in colorectal carcinoma .

结论：应用免疫组化法检测结直肠癌组织中P-gp、 GST-π和 TopoⅡ的表达，对结直肠癌的化疗药物的选择和判断预后具有显著的临床意义。

Conclusions The detection of GST - π and Topo ⅱ - α expressions may be helpful to judge the malignant behavior metastasis and prognosis in human colorectal carcinoma .

结论GST-π和 TopoⅡ -α在结直肠癌组织中的表达与肿瘤的临床病理特征有关，可作为衡量肿瘤恶性程度和预后的指标之一。

Expression and clinical significance of GST - π P-gp Topo ⅱ in colorectal cancer

耐药表型 GST-π、P-gp及 TopoⅡ在大肠癌中的表达及其临床意义

Conclusion P-gp GST - π Topo ⅱ and LRP play important roles in the primary MDR of the colon and rectum carcinoma .

结论P-gp、 GST-π、 TopoⅡ和LRP均在结直肠癌原发性多药耐药中起重要作用。

In the multivariate Cox analysis survival rate was correlated with recurrence lymph node metastasis Topo ⅱ and GST - π( P < 0.05 ) .

经多因素Cox比例风险模型分析显示：局部复发、淋巴结转移及 TopoⅡ、 GST-π的表达与宫颈癌患者术后生存率有关（P<0.05）。

Conclusion The detection of the expression of P-gp 、 GST - π、 Topo ⅱ and TS by immunohistochemistry has important clinical significance for the selection of chemotherapy regimen .

结论采用免疫组化方法检测结直肠癌组织中Pgp、GST π、 TopoⅡ和TS的表达，对肿瘤化疗药物的选择具有重要临床意义；

Determination of trace amounts of chromium (ⅵ) in water by Graphite Furnace Atomic Absorption Spectrometry with electrochemical preconcentration by TOPO chemically modified electrode

TOPO化学修饰电极电 富集 -石墨炉原子吸收法测定水中痕量Cr（Ⅵ）的研究

Expression and significance of Topo - ⅱ in hepatocellular carcinoma

多 药 耐药 相关 蛋白 Topo-Ⅱ在原发性肝细胞癌的表达及意义

Considering mono-drug resistance mechanism CR rate of MDR1 + group was the lowest Topo ⅱ group took the second place and GCR - group was the highest .

单因素耐药机制中，以MDR1+组CR率最低， TopoⅡ -组次之，GCR减低组最高。

Objective : To evaluate the clinical significance of expression of P-glycoprotein ( P-gp ) glutathione S-transferase ( GST - π) and Topoisomerase ⅱ( Topo ⅱ) in colorectal carcinoma .

目的：探讨结直肠癌中P-糖蛋白（P-gp）、谷胱甘肽-S-转移酶（ GST-π）和DNA拓扑酶Ⅱ（ TopoⅡ）的表达及临床意义。

Objective To study the relationship between topoisomerase - ⅱ alpha ( Topo - ⅱ α) expression and pathological grades of astrocytic tumors and approach the value of Topo - ⅱ α in evaluation the prognosis of astrocytic tumors .

目的研究拓扑异构酶-Ⅱα（ topoisomerase-Ⅱα， Topo- Ⅱα）在星形细胞起源肿瘤中的表达与病理分级的关系，并探讨Topo-Ⅱα对判断此类肿瘤患者预后的价值。

In this paper some results are obtained for a continuous self-mapping of topo - logical space with zero entropy .

本文给出了空间连续自映射 拓扑熵等于零的几个充分条件。

The expression of P-gp GST - π and Topo ⅱ in breast cancer and their clinical significance

乳腺癌P-gp、 GST-π及 TopoⅡ的表达及意义

Methods : The expressions of P-gp GST - π and TOPO II were studied by S-P immunohistochemical techniques in cervical cancer tissues from 56 patients and para-carcinoma tissues from 56 patients who had not undergone chemotherapy radiotherapy and immunotherapy and in normal tissues from 30 patients .

方法：免疫组化链霉菌素-生物素（S-P）法对术前未使用过化疗、放疗及免疫治疗的56例宫颈癌及癌旁组织，30例正常宫颈组织行P-gp， GST-π， TOPO检测。