The specialization of mesenchymal stem cells to cardiac muscle cells with trichostatin A intervention in the simulated microenvironment

曲 古 抑菌 素干预骨髓间充质干细胞向心肌细胞特化体外实验

This study was to evaluate enhancive effect of trichostatin A ( TSA ) a histone deacetylase ( HDAC ) inhibitor on the transfection efficiency of adenovirus in ovarian carcinoma cell line A2780 and explore its possible application to adenovirus-based gene therapy .

本研究通过观察组氨酸去乙酰化酶（HistoneDeacetylase，HDAC）抑制剂 Trichostatin A（TSA）对卵巢癌细胞株A2780CAR表达水平的影响，探讨HDAC抑制剂在腺病毒载体基因治疗中应用的可能性。

Targeting multiple signaling pathways in LNCaP prostate cancer cell line by trichostatin A

曲 古 抑菌 素 A对前列腺癌LNCaP细胞抑制效应的细胞信号通路研究

AIM : To investigate the molecular mechanisms underlying the antitumor effect of trichostatin A ( TSA ) on LNCaP prostate cancer cells .

目的：研究组 蛋白去 乙酰化 酶 抑制剂 曲 古 抑菌 素 A（TSA）对前列腺癌LNCaP细胞抑制作用的细胞信号机制。

Effect of Trichostatin A on cell proliferation of breast cancer cell line MDA-MB-231

曲 古 抑菌 素 A对乳腺癌细胞株MDA-MB-231增殖的影响

As the first found natural histone deacetylase inhibitor recent studies have found that Trichostatin A ( TSA ) had inhibitory effect on many tumor cells by inducing tumor cell apoptosis and cell differentiation blocking cell cycles and so on .

曲 古 抑菌 素 A是一种重要的组蛋白去乙酰化酶抑制剂，近年来研究发现，其对多种肿瘤细胞具有抑制作用，作用机理包括诱导肿瘤细胞凋亡、阻滞细胞周期和促进细胞分化等。

An experimental study on the apoptosis of human mucoepidermoid carcinoma cell MEC-1 induced by Trichostatin A

TSA诱导人粘液表皮样癌细胞MEC-1凋亡机制的初步研究

The Studies of Thyroid Carcinoma Cells Re-differentiation Induced with Retinoic Acid and Trichostatin A

维甲酸和 曲 古抑素联合诱导甲状腺癌细胞分化基础研究及维甲酸诱导分化型甲状腺癌的初步临床应用

This study was designed to investigate whether trichostatin A ( TSA ) possesses antitumor activity against Human bladder cancer cell and if any its mechanism .

目的本研究探讨 曲 古 抑菌 素 A（ TSA）对人膀胱癌细胞的杀伤作用和机制。

The Effect of Trichostatin A on Goat Cloned Embryo Development Following Treatment of Donor Cells or Reconstructed Embryos

TSA处理供体细胞或重构胚对山羊克隆胚胎发育的影响

Indeed muscles examined from dystrophic mice treated with Trichostatin A for three months displayed normal tissue architecture as compared to the muscles examined from untreated dystrophic mice .

的确，用 曲 古 抑菌 素治疗数月的肌营养不良鼠与未经治疗的鼠相比显示正常的组织结构。

Effects of Trichostatin A on Inhibiting Growth and Inducing Apoptosis of Thyroid Cancer Cells in Vitro

曲 古 菌 素 A对甲状腺癌细胞增殖及凋亡的影响

Effect of Trichostatin A on Cell Cycle and the Expression of Cell Cycle-Associated Genes in Human Colon Cancer Cell Lines

曲 古 抑菌 素 A对结肠癌细胞株SW480细胞周期影响的机制研究

Trichostatin A inducing apoptosis and cell cycle arrest of bladder cancer cells : the in vitro mechanism

曲 古 霉 素 A体外诱导膀胱癌细胞凋亡及细胞周期阻滞的机制探讨

The Effect of Trichostatin A upon Histone H3 Acetylation in Nuclear Transplantation Donor Cells

曲 古 抑菌 素 A对核移植供体细胞组蛋白H3乙酰化水平的影响

Effect of Trichostatin A on Histone Acetylation Level and Apoptosis in HL-60 Cells

曲 古 菌 素 A对HL-60细胞组蛋白乙酰化水平和凋亡的作用

Objective To investigate the apoptosis of SPC-A-1 cells induced by trichostatin A ( TSA ) .

目的研究 Trichostatin A（TSA）诱导肺癌细胞系SPC-A-1细胞凋亡。

Molecular mechanism of trichostatin A facilitating arsenic trioxide to induce HL-60 cells differentiation

曲 古 抑菌 素 A促进As2O3诱导HL-60细胞分化与分子机制的研究

Enhancive Effect of Histone Deacetylase Inhibitor Trichostatin A on Transfection Efficiency of Adenovirus in Ovarian Carcinoma Cell Line A2780

HDAC抑制剂 TSA增强卵巢癌细胞株A2780对腺病毒基因转染效率的 体外研究

Objective : To investigate the influence of trichostatin A ( TSA ) a histone deacetylase ( HDAC ) inhibitor on the growth of human bladder cancer cells and on the expression of related genes and to explore the mechanism involved .

目的：观察组蛋白去乙酰化酶（HDAC）抑制剂 曲 古 霉 素 A（TSA）对 体外培养膀胱癌细胞生长情况及相关基因表达的影响，并探讨其可能的作用机制。

Previous studies have demonstrated that trichostatin A ( TSA ) specifically inhibits HDAC activity and recruits HAT during transcription so as to augment acetylation of histones and certain transcription-related factors and results in changes of protein biological activities in regulating gene expression .

曲 古 抑菌 素 A（TSA）能够特异性抑制HDAC活性，并在转录过程中募集HAT，使组蛋白和转录相关因子乙酰化，从而改变蛋白质的多种生物学特性，以参与基因表达调控。

OBJECTIVE : To study if trichostatin A facilitates arsenic trioxide to induce HL-60 cells differentiation and explore the underlying mechanism .

目的：研究 曲 古 抑菌 素 A 能否促进小剂量三氧化二砷（As2O3）诱导HL-60细胞分化并对其机制进行初步探讨。

Effect of Trichostatin A ( TSA ) on Histone Acetylation and Methylation in Bovine Fibroblast Cells

曲 古 抑菌 素 A对体外培养牛成纤维细胞组蛋白乙酰化和甲基化的影响

Objective : To investigate the synergistic effects of a histone deacetylase inhibitor trichostatin A ( TSA ) combined with cisplatin ( DDP ) on cisplatin-resistant ovarian epithelial cancer cell line C13 .

目的：本研究探讨组蛋白去乙酰化酶抑制剂 Trichostatin A（TSA）联合化疗药物顺铂（DDP）处理人卵巢癌顺铂耐药株C13的协同效应。

A study of effect of trichostatin A on the expression of cell cycle related protein in K562 cell line

曲 古 菌 素 A对K562细胞周期蛋白的影响

Inhibitory Effect of Trichostatin A Combined with Rosiglitazone on Proliferation of Stomach Cancer Cells

曲 古 抑菌 素 A与罗格列酮联合应用对胃癌细胞增殖的抑制作用

HDAC Inhibitor Trichostatin a Promotes the Specialized Differentiation of Mesenchymal Stem Cells and Investigate to Mechanism of Acetylated Action

TSA对骨髓间充质干细胞定向分化的促进作用及机制探讨

Several studies reported that trichostatin A ( TSA ) promoted the differentiation of MSCs to the osteoblast and adipocyte cells .

也有文献报道 曲 古 抑菌 素 A（TSA）可促进MSCs向成骨细胞和脂肪细胞分化。

Trichostatin A inhibits the growth of human gastric cancer SGC-7901 cells

曲 古 抑菌 素 A对胃癌细胞生长的抑制作用

Effects of trichostatin A effects on natural killer cell survival and activity

曲 古 抑菌 素 A 对外 周 血自然杀伤细胞活性和功能的影响