Design and Synthesis of Small Antitumor Agents Acting on the Colchicine Site of β - Tubulin ; Molecular mechanisms of miRNA and their application to drug research

基于 微管 蛋白小分子抗肿瘤药物的设计与合成研究微小核糖核酸的分子机制及其在药物设计中的应用

Cloning and Sequence Analysis of β - Tubulin Gene Fragments of Neosinocalamus affinis

慈竹β -tubulin基因片段的克隆及序列分析

Effect of terminal warm blood cardioplegia on the changes of tubulin in myocardial cells after hypothermic ischemia and reperfusion Electroencephalogram in Deep Hypothermia and Low-Flow Cardiopulmonary Bypass

终末温血灌注对低温缺血再灌注心肌细胞 微管 蛋白的影响体外循环深低温低流量灌注的脑电图变化

The Response of Metabolism and Tubulin of Cardiac Myocytes in vitro to Mechanical Stretch

体外培养心肌细胞代谢和 微管 蛋白对拉伸应变的响应

The protein out of which microtubules are made is called tubulin .

构成微管的蛋白质叫做 微管 蛋白。

Prokaryotic expression and purification of human beta tubulin 2C protein

人β- 微管 蛋白2C蛋白的原核表达与纯化

Expression of β - tubulin III and Bcl-2 and the clinical significance in non-small cell lung cancer

β- 微管 蛋白Ⅲ，Bcl-2在非小细胞肺癌中的表达及临床意义

Prokaryotic Expression of α - tubulin Gene of Camellia sinensis and Preparation of α - tubulin Polyclonal Antibody

茶树α -tubulin基因的原核表达及其多克隆抗体的制备

The dynamic changes of MT included : MT disaggregated into tubulin and a flat-shaped microtubules-network was reorganized .

微管的动态变化包括解聚成 微管 蛋白及重组成扁平形微管网。

As a kind of antimitotic drugs Vinca alkaloids can inhibit microtubule assembly and induce tubulin self-association into coiled spiral aggregates .

长春花生物碱作为一类抗有丝分裂药物，能够抑制微管聚合并诱导聚合的 微管 蛋白解聚。

JWA protein binds to α - tubulin and regulates microtubule stability

JWA蛋白与α- 微管 蛋白结合和对微管稳定性的调节

Its physiological function is promoting tubulin polymerization into microtubules stabilizing micro-tubular structure and maintaining nerve function .

Tau蛋白具有促进 微管 蛋白聚合成微管、稳定微管结构和维持神经功能的作用。

The plasma concentrations of P - tubulin and APP are the potential biomarker for diagnosing AD.

血浆 β -tubulin和APP浓度有可能成为AD的生物学诊断指标之一，将 两者 相 结合，有可能能够提高诊断的特异性和敏感性。

We detected the expression levels of miRNA targets by qRT-PCR with tubulin as internal control .

利用qRT-PCR技术，以 Tubulin为内参基因，我们检测了miRNA靶基因的表达。

Temperature-Controlled Molecular Dynamics Studies on the Folding Mechanism of the Tubulin Active Peptides

温控分子动力学研究 微管 蛋白活性肽链的折叠机制

Methods Tubulin protein was extracted from rabbit brain .

方法 我们从兔脑组织中纯化出 微管 蛋白，并纯化出 原 核表达的 TAU 和 PRP 蛋白。

Role of heat shock protein 90 and tubulin in oxidative stress preconditioning

Tubulin和HSP90在氧化应激预适应中的作用

By docking simulation the binding modes of the colchicine-site inhibitors with β - tubulin and their structural model were constructed .

采用对接的方法建立了秋水仙碱位点抑制剂与 微管 蛋白的结合模式，并构建了其结构模型。

It possesses a unique mechanism of action as promoters of tubulin aseembly and inhibitors of microtubule disassembly .

它的作用机理独特，通过诱导和促进 微管 蛋白聚合形成稳定结构，从而抑制微管解聚。

Objective To study the mechanism of β - Elemene in antitumor by analyzing the polymerization of tubulin in vitro .

目的探讨β&榄香烯对 微管 蛋白体外聚合作用的影响，阐明其抗肿瘤的作用机制。

After in vitro fertilization and parthenogenetic activation - tubulin concentrated around the male and female chromatin and pronuclei .

体外受精和孤雌活化后，γ 微管 蛋白聚集在雌雄原核的周围。

Primary antibodies used in experimental groups are IgG from MG patients and NF-160 or P Tubulin ;

实验组分为两组，一抗用MG患者IgG分别与NF-160和β -Tubulin作双标；

The Relationships between Structure and Function of JWA Binds to α - tubulin

JWA与α- 微管 蛋白结合的结构和功能关系研究

Taxol is tubulin polymerization and stability in the role of the split caused rapid tumor cells in the mitotic phase was firmly fixed so that the cancer cells by blocking reproduction and death .

紫杉醇具有聚合和稳定 微管的作用，致使快速分裂的肿瘤细胞在有丝分裂阶段被牢牢固定，使癌细胞复制受阻断而死亡。

The cells were observed actin protein tubulin and vimentin form and content .

观察各组细胞微丝蛋白、 微管 蛋白和波形蛋白的形态及含量变化。

Aim To study the effect of 5F on tubulin polymerization .

目的研究半边旗提取物5F对 微管 蛋白聚合的影响。

Dynamic changes of β - tubulin - ⅲ in the early directed differentiation from the spinal cord neural stem cells to neurons

β- 微管 蛋白-Ⅲ在脊髓神经干细胞向神经元定向分化早期的动态变化研究

Combined Effect of Di-n-butyl Phthalate and Benzo ( a ) pyrene on Vimentin and α - tubulin in Rat Sertoli Cells

邻苯二甲酸二丁酯和苯并aw_735芘对大鼠睾丸支持细胞波形蛋白和 微管 蛋白 表达的影响

These drugs block cancer growth by binding to the tubulin proteins needed for cell division .

这类药物和细胞分裂有关的 微管蛋白结合后可抑制肿瘤细胞的生长。

OBJECTIVE : To study the effect of tubulin polymerization and antitumor in vitro affected by β - elemene .

目的：观察β-榄香烯对体外 微管 蛋白聚合 与 解聚的影响及抗肿瘤疗效。