Purpose To study the effects of pioglitazone on the renal fibrosis of uninephrectomized diabetic rats and its possible mechanisms .

目的观察盐酸吡咯列酮对 单 肾 切除的糖尿病大鼠肾脏纤维化的影响，并从纤维化 相关 基因 表达 改变 的 角度探讨其机制。

Thus the STZ - injected uninephrectomized rats developed overt diabetic nephropathy as evidenced by the development of hypertension progressive proteinuria and renal dysfunction .

结论 给 单侧 肾 切除的大鼠静脉注射 低剂量STZ可以诱发糖尿病性肾病模型，具有高血压、进行性蛋白尿、肾功能不良的体征。

Methodology : Diabetes was induced in uninephrectomized SD rats by intraperitoneal injection of STZ ( 65 mg / kg ) . Losartan ( 40mg / kg ) was administered daily by gavage from the next day of the induction to diabetes for 12 weeks .

方法： 单侧 肾切除大鼠腹腔注射STZ诱发糖尿病模型，每日灌胃给予 AT1Ra氯沙坦（40mg/kg），共12周。

Effects of indomethacin on contents of camp and cGMP in compensatory hypertrophic kidneys of uninephrectomized rats

消炎痛对大鼠 代偿性肥大肾内cAMP和cGMP含量的影响

Methods Uninephrectomized male Wistar rats were used to induce diabetic models by ip Streptozocin ( 65 mg / kg ) .

方法ip链脲佐菌素（ 65mg/kg）诱发糖尿病大鼠模型，每日ip葛根素注射液， 共 16 周。

Methods : The glomerulosclerosis rat models were prepared by injected adriamycin twice time into the uninephrectomized rats and the effect of POT on genetic expression of renal cortex TGF - β 1 in glomerulosclerosis rats was observed .

方法：采用 单侧 肾 切除 加2次注射阿霉素制备肾小球硬化大鼠模型，观察带蒂大网膜包肾术对肾小球硬化大鼠肾皮质TGF-β1基因表达的影响。

Serum nitrogenous metabolites and compensatory renal growth in uninephrectomized rats

一侧 肾 切除大鼠血清含氮代谢物与肾代偿性生长