Pilot application of isolated perfused rat kidney model for discovery and evaluation of uricosuric drug

离体大鼠肾脏灌流 技术在发现和评价 促 尿酸 排泄药物中的初步应用

Aim To establish a in vitro model for discovery and evaluation of uricosuric drug we established a reliable rat isolated perfused kidney ( IPK ) preparation and observed urate excretion characterization in absence or presence of probenecid in perfusate by IPK .

目的为建立发现和评价 促 尿酸 排泄药物作用的离体模型，采用离体大鼠肾脏灌流技术，观察尿酸在离体肾脏中排泄特点和丙磺舒对尿酸排泄影响。

Conlusion : As same as Narcaricin mite the domestic Benzbromarone is an effective and safe uricosuric medicine and is convenient to use .

结论：国产苯溴 马龙胶囊是一强力排尿酸药，使用方便安全。