Re sults The substitution at position of 87 had no effect on the cytotoxicity of TM-TNF but the mutein could induce the change of target cell death manner from apoptosis to necrosis and promote NF - κ B translocation from the cytoplasm into nucleus .

结果87位氨基酸置换后，TMTNFα对靶细胞的杀伤率无明显改变，但TMTNFα突变体通过促进NFκB 核转位，诱导 靶细胞死亡的方式由凋亡转为坏死。

The zeroth-order nuclear potential is taken tobe Woods-Saxon potential . The non-spherical symmetric part V_1 of the nuclear potential induced by the vibration of the target nucleus is considered as a perturbation .

考虑了核力势和库仑势，零级近似核力势取为Woods-Saxon势，由 靶 核振动引起的核力势的非球对称部分V1作为微扰。

N TARGET The curriculum target should be regarded as the nucleus .

四大目标的 核心是课程 目标。

On the Target Fragments in High Energy Nucleus - Nucleus Collisions

高能 核&核碰撞的 靶 核碎片研究

Target derived neurotrophins bind to and induce phosphorylation of trk receptors at the axonal terminal . Active trk or NT trk or other signal molecules can be retrogradely transported along the axon to transduct messages to neuronal nucleus .

靶源性NTs的作用由轴突末端trk受体介导，以磷酸化状态的trk或NT－trk复合物或被活化的其它信使分子等形式沿轴突逆行运输至胞 浆 胞 核，实现其信号转导。

Method Two PD patients underwent microelectrode - guide stereotaxic DBS surgery left Vim ( ventral intermediate thalamic nucleus ) as target case 2 target in patients were bilateral STN ( subthalamic nucleus ) as target in patient 2.Result After operation all parameters were stable .

方法2例PD患者进行了手术，采用立体定向系统，以微电极引导将刺激电极植入相应靶点，例1选择丘脑腹中间核（Vim），例2选择 丘脑底 核（STN）为 靶点。