Since the discovery of thienamycin carbapenem antibiotics imipenem cilastatin panipenem betamipron and meropenem have been used in clinical treatment of severe bacterial infections caused by multidrug resistant strains .

自 硫 霉 素 被发现以来，碳 青霉烯类抗生素亚胺培南西司他丁、帕尼培南倍他米隆和美罗培南已用于临床多种耐药菌引起的严重感染的治疗。