The combined tumorigenic and angiogenic effects of S1P make it an excellent target for anticancer therapy .

其 致 瘤和促血管生成的双重作用使得S1P成为一个作为抗癌治疗非常好的靶点。

Study on the Immunology and Apoptosis of Chicken and Tumorigenic Mouse Induced By SAg-SEB and MDV

SAg-SEB和MDV诱导雏鸡与 荷 瘤小鼠免疫学变化及细胞凋亡的研究

HER-2 was proved to be tumorigenic oncogene and over-expressed in 25 % ~ 30 % of the breast cancer .

流行病学调查发现：作为 肿瘤 发生的癌基因，HER-2在25%～30%的乳腺癌中过表达。

Study on tumorigenic mechanism of human leukemia cell line in nude mice

人白血病细胞系在 胸腺 缺陷裸鼠体内 致 瘤机制研究

The in vitro proliferation of C6 / IL-18 cells was detected by MTT colorimetry and flow cytometry . The rat model was used to observe the tumorigenic activity of the C6 / IL-18 cells .

用MTT比色法检测细胞体外增殖的状况，用流式细胞技术检测细胞的增殖活性，并建立大鼠胶质瘤模型，观察 C6/IL18细胞 体内 致 瘤 性 的 改变。

This genetic signature of tumorigenic breast-cancer cells was even more strongly associated with clinical outcomes when combined with the WR signature in breast cancer .

遗传 性乳腺癌细胞的遗传特性会同临床结果有较好的相应，在乳腺癌患者中结合伤口反应指数时。

Nude mice transplantation showed all C6 single cells were tumorigenic and the xenograft tumor cells had the similar CSC properties as their mother cells .

裸鼠致瘤实验发现所有参与种植的C6单细胞 克隆株 均可 成 瘤，且 种植瘤子 代细胞同样具有肿瘤干细胞样特性，与母代细胞一致。

Differential gene expression analysis of human leukemic cell line with different tumorigenic potentials in nude mice

人白血病不同 致 瘤潜能细胞系的基因表达差异分析

We developed an immunodeficient mouse model to test the tumorigenic potential of different populations of cancer cells derived from primary unmanipulated human HNSCC samples .

我们从未经处理的原发性人类HNSCC样本分离出不同的癌细胞群体，并建立免疫缺陷性老鼠模型测试这些癌细胞群体的潜在 致 肿瘤 性。

Conversion of a Hepatocyte Cell Line into a Tumorigenic Cell Line by ras or myc Oncogene

ras和myc癌基因对肝细胞系的转化 活性及转化细胞的 诱 瘤 性的研究

The objective of this study is to confirm the oncogenic and tumorigenic potential of the transformed NIH3T3 cells transfection mediated with TIF3 .

本研究的目的是对TIF3基因转化NIH3T3细胞的致癌能力和 致 瘤 性进行鉴定。

There is an obvious enhancement of proliferation migration and tumorigenic ability in anoikis-resistant osteosarcoma cells . 4 .

骨肉瘤失巢凋亡抵抗细胞增殖能力、迁移能力、 裸鼠 成 瘤能力明显增强。

S100A4 knockdown in HN-CICs reduced their self-renewal capability and their stemness and tumorigenic properties both in vitro and in vivo .

S100A4敲除的 HN-CICs，体内积体外的自我更新能力、干性及 致 瘤性均下降了。

Results Normal biological characteristics and cell function could be maintained in non tumorigenic transformed cell but it was changed markedly in malignant transformed cell .

结果一般转化细胞无 致 瘤 性， 大都能保持其正常细胞的生物学特性和功能，而恶性转化细胞其生物学特性和功能明显改变。

In recent years studies have shown that there are a small number of cancer stem cells in brain gliomas which have the characteristics of neural stem cell . They have the potential of self-renewal multi-differentiation and in vivo tumorigenic .

近年来有研究表明，脑胶质瘤内存在少部分的肿瘤干细胞，具有神经干细胞特性，有进行自我更新、多向分化及体内 致 瘤的潜力，是肿瘤发生、发展的根源。

It is assumed that this tumorigenic feature will be manifested upon transplantation to human patients as well .

推测这种 致 瘤特征在干细胞被移植到人类病人时也可显现。

In vitro analysis of the function of Nlp indicated that it conferred on cells tumorigenic properties suggesting that it was an oncogenic protein .

通过体外对Nlp功能研究显示它可使细胞 癌变，提示这是一种原癌蛋白。

Establishment and tumorigenic ability of immortalized human marrow mesenchymal stem cell

永生化人骨髓间充质干细胞系的建立及 致 瘤 性 的 检测

Anomalous proteins engaged in support of this tumorigenic regulatory environment most probably represent optimal intervention targets in a heterogeneous population of cancer cells .

此致 瘤调节环境支持中异常蛋白的 嵌入可能很大 程度上体现了在肿瘤细胞中异质群体内靶目标干预的最佳化。

Additionally the tumors derived from the highly tumorigenic pancreatic cancer cells appeared remarkably similar to the appearance of tumors taken directly from patients Simeone said .

Simeone说，“而且，来自于高 致 瘤 性的胰腺癌细胞的肿瘤非常类似于直接来自于患者的肿瘤”。

Bladder cancer stem cells-related Bmi-1 gene has a structural abnormality and genetic repair can reduce the ability of EMA-CD44v6 + subset cells in tumorigenic .

结论膀胱癌EMA-CD44v6+亚群细胞有起始和维持肿瘤的能力，具有肿瘤干细胞特性；膀胱癌干细胞相关Bmi-1基因有结构异常，基因修复对降低 EMA-CD44v6+亚群细胞的 致 瘤能力有一定效果。

Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells .

骨形成蛋白能抑制人类脑部肿瘤起始细胞的 致 瘤潜能。

Conclusion HCV-C protein showed human normal biliary epithelial cells transformation and tumorigenic features .

结论 HCV-C蛋白具有促胆管细胞转化和促进 肿瘤 发生的作用。

Recently it has been found there is a small group of highly tumorigenic ability cells in tumor these cells may be derived from the transformation of normal stem cells .

近期发现在肿瘤组织中存在着一小群具有高 致 瘤能力的细胞，这些细胞可能源自于正常干细胞的转化。

Nude mice transplantation showed only human glioblastoma cells which could form tumor-spheres were tumorigenic and the xenograft tumor cells also contained CSCs .

裸鼠 致 瘤实验发现人胶质母细胞瘤中只有克隆球形成能力的细胞具有 致瘤能力； 种植 瘤中的子代细胞同样有母代肿瘤干细胞样细胞的存在。

Tumorigenicity different groups of BMSCs cells to nude mice tumor formation experiment test results show that the group BMSCs cells are not tumorigenic .

裸鼠接种肿瘤形成实验检验不同组别的BMSCs细胞的致瘤性，结果表明，各组别BMSCs细胞均不 具有 致 瘤 性。

Affecting Tumorigenic Mouse Immune Function and Antioxidase of QY - ⅰ from Earthworm

蚯蚓QY-Ⅰ对 荷 瘤小鼠免疫功能及抗氧化酶的影响

Citrinin is a mycotoxin which can induce renal dysfunction and it is tumorigenic .

桔青霉素是能引起肾脏毒性的真菌毒素，并有 致癌性。

Furthermore we found that HPV-positive dysplastic and tumorigenic cervical lesions were characterized by high levels of EZH2 protein in vivo .

并且，研究发现，HPV阳性的发育异常的以及 致 瘤颈损伤以EZH2的高表达为特征。

Conclusion : The present study suggests that the transformed cells induced by three nickel compounds were malignant with tumorigenic ability .

结论：本文进一步说明了三种镍化合物所诱发的细胞转化为恶性转化， 且都 具有 体内 致 瘤 性。