An attempt to remove the trityl group of compound 3 under acidic conditions gave the new compound 4 . The structures of the compounds 3 and 4 were confirmed by elementary analyses and spectroscopic methods .

化合物3在酸性条件下脱 保护， 制 得化合物4。用元素分析和波谱方法确定化合物3和4的结构，用 杯盘 培养法测化合物4的 抑菌 活性。

The influences of reactant ratio reaction temperature reaction time on substitution reaction were studied . The better reaction conditions were obtained : molar ratio of trityl chloride and cuprous cyanide was 1:1.3 reaction temperature was at 130 ℃ reaction time was 2.5h .

并通过对原料配比、反应温度和反应时间的研究，得到了较佳的合成工艺条件： 三 苯基氯甲烷与氰化亚铜的最佳摩尔比为1：1.3，反应温度为130℃，反应时间为2.5小时。

Spectroscopic characterization of the compound and ASED-MO calculation of the trityl cation are reported .

同时 还研究了该化合物的谱学性质，并用 ASE&MO方法计算了 它 的 电子 结构。

One-step Transformation of the Trityl Ether to the Acetonide

三 苯 甲基醚 直接 转化 成 丙酮 化合物 的 反应

Methods 3-one-12-hydroxy-13 was synthesized in a three-step route including protecting primary alcohol of andrographolide by trityl ether oxidating secondary alcohol and removing protecting group etc.

方法通过 三 苯甲醚保护伯醇、氧化仲醇、脱去保护基的方法，合成3酮基12羟基 13烯穿心莲内酯。