Effect of valproic acid on the expression of VEGF and bFGF in Kasumi-1 cell

丙戊酸钠对Kasumi-1细胞VEGF、bFGF表达的影响

Monitoring of the Blood Concentration of Valproic Acid in 1 460 Cases with Epilepsy

1460例次癫痫患者 丙 戊酸 血 药浓度监测分析

Analysis of Correlation between Blood Concentration of Valproic Acid and the Content of Plasma Protein

丙 戊酸 血 药浓度与血浆蛋白含量的相关性分析

Estimation of relative clearance of valproic acid with nonlinear mixed effect model in epileptic out-patients

非线性混合效应模型法估算门诊癫痫患者 丙 戊酸的相对清除率

The Study of Influence and Significance of Angiogenesis Relative Factors on Kasumi-1 Cell Line Treated with Valproic Acid

丙戊酸钠对Kasumi-1细胞株血管新生相关因子表达的影响及意义的研究

After administration of valproic acid ( VPA ) elevated levels of NPY were found both in hippocampus and in cortex .

给予 丙戊酸钠（VPA）治疗发现可增高海马和皮层NPY浓度。

Effects of Valproic Acid on Function Recovery of Injuried Spinal Cord with Transplanted Neural Stem Cells in Adult Rats

丙 戊酸对神经干细胞修复损伤脊髓功能的影响

Valproic acid inhibits the cardiomyocyte hypertrophy induced by angiotensin ⅱ in rats

丙 戊酸抑制血管紧张素Ⅱ致大鼠心肌细胞肥大

Valproic Acid Activates ERK-1 / 2 Signaling Pathway in The Rat Hippocampus and Frontal Cortex

丙戊酸钠活化大鼠海马和额叶ERK-1/2信号传导通路

Determination of free valproic acid in human serum

游离 丙 戊酸血清 药物 浓度的测定

A Experimental Study on Repair and Regeneration of Rat Sciatic Nerve Injury by Valproic Acid

丙戊酸钠对鼠坐骨神经损伤修复与再生的实验研究

Relativity of Valproic Acid Concentration in the Blood and its Antiepilepsy Effect

丙戊酸钠 血 药浓度与抗癫癎作用的相关性

OBJECTIVE : To observe the factors that influence the fluctuation of serum concentrations of valproic acid and to improve the effectiveness and usefulness of monitoring the serum concentration .

前言：目的：探讨影响 丙戊酸钠 血 药浓度波动的因素，提高丙戊酸钠血 药浓度检测的有效性及可利用性。

Drug-induced pulmonary eosinophilia was suspected and valproic acid was discontinued .

因为可疑为药物引起的肺嗜酸细胞增多症， 丙 戊酸被停用。

OBJECTIVE : To established a HPCE method for the content determination of the principal agent in valproic acid tablets .

目的：建立以高效毛细管电泳法测定 丙 戊酸片中主药含量的方法。

Aim To study the relation between dosage and serum concentration of valproic acid in children with epilepsy .

目的研究儿童癫痫服用 丙 戊酸后血 药浓度与 给 药剂量的关系。

Effects of chronic valproic acid sodium treatment and withdrawal on glutamate and glutamine release of C6 glioma cells

丙戊酸钠慢性作用及停药后对C6神经胶质瘤细胞释放谷氨酸和谷氨酰胺的影响

Objectives : To investigate the effect of valproic acid ( VPA ) and carbamazepine ( CBZ ) upon electroencephalogram .

目的：探讨 丙戊酸钠（VPA）和卡马西平（CBZ）对脑电图的影响。

Investigation of influence of valproic acid phenytoin phenobarbital to relative clearance of carbamazepine and its epoxide metabolite

非线性 混合 效应 模型考察 丙 戊酸、苯妥英和苯巴比妥对卡马西平及其环氧化代谢产物相对清除率的影响

Valproic Acid ( VPA ) a histone deacetylase inhibitor could specifically inhibit the histone deacetylase activity increase histone acetylation and active gene expression in somatic cells .

丙 戊酸（ valproic acid，VPA）作为一种组蛋白去乙酰化酶抑制剂，能特异性抑制组蛋白去乙酰化酶的活性，提高细胞内组蛋白乙酰化水平，激活基因的表达。

176 cases were involved in the evaluation of adverse reaction and the rate of adverse reaction of valproic acid was 5.7 % .

纳入不良反应评价的176例 癫痫 患儿 丙 戊酸的不良反应发生率为5.7%；

The curative effect evaluation of two formulations of valproic acid to secondary epilepsy

不同 丙戊酸钠制剂治疗继发性癫痫的疗效评价

Objectives To investigate the effects of Valproic acid ( VPA ) on the proliferation of human ovarian carcinoma cell line A2780 and the expression of angiogenesis and metastasis related factors ( VEGF 、 MMP-9 、 MMP-2 and E-cadherin ) .

目的研究 丙 戊酸（VPA）对人卵巢癌A2780细胞生长及血管生成和转移相关因子（VEGF、MMP-9、MMP-2、E-cadherin）表达的影响。

Objective : To investigate a new and more suitable method for monitoring serum concentration of valproic acid and evaluate its clinical application .

目的：探讨一种新的更适合临床应用的 丙 戊酸 血 药浓度监测方法，评估其临床应用价值。

Monitoring of the Serum Concentration of Valproic Acid and Drug Administration with Individuation in 190 Epileptic Patients

190例癫痫患者 丙 戊酸血浓度监测及个体化 给药

Conclusion : carbamazepine ( except for infantile spasms ) and valproic acid should be the first line drugs in the treatment of patients with epilepsy the best serum therapeutic concentrations are 6 - 8 μ g / ml and 60 - 90 μ g / ml respectively .

结论：卡马西平（除婴儿痉挛外）和 丙 戊酸 宜作为癫痫患者的首选药物，血清浓度分别 宜控制在6～8μg/ml和60～90μg/ml。

The relation between valproic acid dosage and serum concentration in children with epilepsy

儿童 丙 戊酸 血 药浓度与 给药剂量

Model of spina bifida occulta induced by valproic acid in foetal rats

丙 戊酸诱导胎鼠发生隐性脊椎裂畸形的模型建立

Methods : Concentration of valproic acid in serum of epileptic children was detected by Capillary column gas chromatography with a rising column temperature program and the relationships between serum concentration clinical effects adverse reaction and quality of their life were analyzed .

方法：程序升温毛细管气相色谱法测定癫痫患儿血清中 丙 戊酸浓度，分析 癫痫患儿血 药浓度与临床疗效、不良反应及生活质量之间的关系。

Different concentrations of valproic acid was given to human gastric cancer cells to observe cell morphology .

以不同浓度 丙戊酸钠 诱导人胃癌耐药细胞并观察细胞形态。