Macrolides which are used for the treatment of the infections of respiratory system digestive system and uropoietic system in clinical application led to serious bacterial resistance because they were abused . This became major threat to successful treatment of infectious diseases .

用于治疗呼吸道感染和 皮肤 软 组织感染的大 环内酯类抗生素由于其在临床的 广泛使用， 特别是滥用，导致许多细菌对该类抗生素产生了严重的耐药性，给临床治疗带来了 极大困难。