The starting dose of paclitaxel was 20 mg / m 2 once weekly IV over 3 hours with a subsequent dose escalation of 10 mg / m 2 in cohorts of three new patients .

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A subsequent larger dose of PAT ( 24 Or 36 mg / kg ) tlsuaUy induced ventricular fibrillation ( VF ) by itself .

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Method : 316 post cardiac operation patients with atrial fibrillation Intravenous loading dose of 3 ~ 5mg / kg of amiodarone was given within 10 minutes followed by 0.5 ~ 1.0mg/min infusion . The subsequent dose decreased according to the clinical status .

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Conclusions Low dose U-VA irradiation could induce adaptation reaction which protects cultured skin melanocytes from damages by subsequent challenged dose of UVA . The period the adaptation reaction lasts and protective extents are clearly related to the accumulated dosage of repeated low dose UVA irradiations and intervals .

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