Conclusions The anti angiogenesis of suramin is due to reducing the receptor expression and inhibiting the combination of VEGF and it 's receptors .

结论 苏拉 明 抑制 食管 癌血管生成的 作用 机制 可能是通过抑制血管内皮细胞上的VEGF受体表达，减少VEGF与其受体结合所致。

· AIM : With the effect of PDGF and IL-1 investigate effects of suramin on proliferation of cultured human retinal pigment epithelial ( RPE ) cells in vitro .

目的：研究在血小板源性生长因子（PDGF）和白介素-1β（IL-1β）作用下 苏拉 明（ suramin）对培养的人视网膜色素上皮（retinapligmentepithel-um，RPE）细胞增殖的影响。

Conclusion Suramin has the long-term effect on the inhibition of RPE cells induced by serum especially the inhibitive effect after the remove of suramin which indicates the specific double-peak inhibition during the whole process .

结论 苏拉 明对血清诱导的RPE细胞增生具有长时间的抑制作用，特别是在撤除药物后还能再次引起后抑制作用，整个过程呈现特殊的双峰型抑制效应。

Anti-angiogenesis effect of suramin in esophageal cancer

苏拉 明对食管癌血管生成抑制作用研究

Suramin : discovered in1921 used for the treatment of the first stage of T.b.rhodesiense .

苏拉 明：于1921年发现，用于治疗布氏罗得西亚锥虫的第一阶段。

The drug suramin which is used to kill invading trypanosomes is accumulated in lysosomes .

用杀死侵入的锥虫的药物 苏拉 明，在溶酶体中积累。

Objectives : To examine the effects of suramin on the growth cell cycle and apoptosis of a hormone refractory prostate cancer cell line PC 3M and to explore the possible mechanisms .

目的：观察 苏拉 明对激素非依赖性前列腺癌（HRPC）PC3M细胞生长、细胞周期和凋亡的影响，初步探讨其作用机制。

Inhibitory effects of suramin on corneal neovascularization after corneal alkali burn

苏拉 明对角膜碱烧伤新生血管抑制作用的研究

Influence of Suramin on the Proliferation of Prostatic Carcinoma Cells PC-3M

苏拉 明对前列腺癌PC-3M细胞生长的影响

The experimental study of antiproliferative effect of suramin on trabeculectomy in rabit

苏拉 明辅助用于兔小梁切除术中抗增殖作用的实验研究

Result Suramin is able to suppress the growth and collagen synthesis of keloid fibroblasts . Meanwhile the collagen synthesis of keloid fibroblasts induced by TGF -β 1 is obviously suppressed .

结果 苏拉 明对KFb的生长及胶原合成均有抑制作用，且能明显抑制TGF－β1对KFb胶原合成的诱导作用。

RESULTS : In DDP Suramin and combination groups tumor growth was suppressed significantly with growth inhibitory rates of 23.0 % 34.4 % and 56.3 % respectively ( P < 0.05 ) .

结果：顺铂组、 苏拉 明组、顺铂加 苏拉 明组肿瘤的生长明显受到抑制，瘤 重明显低于对照组，其抑瘤率分别为23.0%、34.4%、56.3%，而联合 用药组抗瘤 作用 进一步 增强。

Effects of Suramin in Combination with Cisplatin on Growth and Metastasis of Lung Adenocarcinoma Xenografts in Mice

苏拉 明联合顺铂对肺腺癌小鼠移植瘤生长和转移的影响

In the 4 treatment groups 31.25 μ g / ml suramin with different concentrations of bFGF ( 1 10 100 and 500 ng / ml ) were added to the medium .

实验组4组，培养基中除加入3125μg/ml的 舒拉明 外，还分别加入终浓度为1、10、100和500ng/ml的bFGF。

Effects of Suramin on the rat hepatic stellate cell in vitro

抗 血管 生成 药 苏拉 明对大鼠肝星状细胞的影响

IC ( 50 ) of it for suramin was 123.2 μ / ml when tested by in vitro sensitivity test .

在以体外药敏试验测定时，其IC50为 123.2μg／ml。

Study of the inhibitory effect of suramin on the angiogenesis of lung cancer

苏拉 明对肺癌血管生成的抑制作用

Chronic suramin treatment effectually prevented the developments of pulmonary hypertension thickening of pulmonary arteriole and right ventricular hypertrophy induced by hypoxia .

经 苏拉 明处理，可明显减轻低氧所致的肺动脉压升高、肺血管壁增厚和右心室肥厚。

Effect of peptide growth factors and suramin on proliferation of human meningioma cells in vitro

肽类生长因子及 苏拉 明对体外培养人脑膜瘤细胞生长的影响

Expressions of HIF-1 α and P-Selectin induced by Suramin combination with Quercetin in lung adenocarcinoma in mice

槲皮素联合 苏拉 明对肺腺癌小鼠 移植瘤HIF-1α和P-选择素表达的影响

Objective To study the inhibiting effects of suramin on FGF induced proliferation of cultured RPE cells and discuss the effects and mechanisms of suramin in the prevention of proliferative vitreoretinopathy ( PVR ) .

目的探讨 舒拉明抗增生性玻璃体视网膜病变（PVR）的作用及机制。

CONCLUSION VEGF plays an important role in the process of hypoxia pulmonary hypertension and suramin can prevent hypoxia pulmonary hypertension by inhibiting the role of VEGF . -

结论VEGF参与了慢性低氧性肺动脉高压的形成， 苏拉 明通过抑制VEGF的作用而有效地降低低氧所致的肺动脉高压。